Controlling stem cell behavior with decellularized extracellular matrix scaffolds.

ABSTRACT: Decellularized tissues have become a common regenerative medicine platform with multiple materials being researched in academic laboratories, tested in animal studies, and used clinically. Ideally, when a tissue is decellularized the native cell niche is maintained with many of the structural and biochemical cues that naturally interact with the cells of that particular tissue. This makes decellularized tissue materials an excellent platform for providing cells with the signals needed to initiate and maintain differentiation into tissue-specific lineages. The extracellular matrix (ECM) that remains after the decellularization process contains the components of a tissue specific microenvironment that is not possible to create synthetically. The ECM of each tissue has a different composition

SUBMITTER: Agmon G 

PROVIDER: S-EPMC4979580 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature