Immediate versus delayed prostatectomy: Nationwide population-based study (.).

ABSTRACT:

Objective

The aim of this study was to compare the outcome of immediate versus delayed radical prostatectomy (RP) in men with low-grade prostate cancer.

Materials and methods

The study included a nationwide population-based cohort in the National Prostate Cancer Register of Sweden, of 7608 men with clinically localized, biopsy Gleason score 6 prostate cancer who underwent immediate or delayed RP in 1997-2007. Multivariable models compared RP pathology, use of salvage radiotherapy and prostate cancer mortality based on timing of RP (< 1, 1-2 or >2 years after diagnosis). Median follow-up was 8.1 years.

Results

Men undergoing RP more than 2 years after diagnosis had a higher risk of Gleason upgrading [odds ratio 2.93, 95% confidence interval (CI) 2.34-3.68] and an incre

SUBMITTER: Loeb S 

PROVIDER: S-EPMC4979613 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature