Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates.

ABSTRACT: This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(?-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via (1)H and (13)C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.

SUBMITTER: Dmochowska B 

PROVIDER: S-EPMC4979630 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature