Ontology highlight
ABSTRACT:
SUBMITTER: Weishaupt MW
PROVIDER: S-EPMC4979738 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20160712
Vaccines against S. pneumoniae, one of the most prevalent bacterial infections causing severe disease, rely on isolated capsular polysaccharide (CPS) that are conjugated to proteins. Such isolates contain a heterogeneous oligosaccharide mixture of different chain lengths and frame shifts. Access to defined synthetic S. pneumoniae CPS structures is desirable. Known syntheses of S. pneumoniae serotype 3 CPS rely on a time-consuming and low-yielding late-stage oxidation step, or use disaccharide bu ...[more]