A meta-analysis for efficacy and safety evaluation of transcatheter left atrial appendage occlusion in patients with nonvalvular atrial fibrillation.

ABSTRACT:

Objectives

This meta-analysis was conducted to evaluate the efficacy and safety of transcatheter left atrial appendage (LAA) occlusion in patients with nonvalvular atrial fibrillation.

Methods

The randomized controlled trials (RCT) or observational studies with any transcatheter LAA occlusion devices were searched in PubMed, Embase, and Cochrane library from inception to November 2015. The incidence rates from individual studies were combined to evaluate the procedural efficacy and safety, including all-cause death, cardiac/neurological death, stroke, transient ischemic attack (TIA), thrombosis, hemorrhagic complications, and pericardial effusion/tamponade.

Results

Thirty-eight studies involving 3585 patients and 6 different occlusion devices were eligible for our inc

SUBMITTER: Wei Z 

PROVIDER: S-EPMC4979802 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature