Effect of perioperative crystalloid or colloid fluid therapy on hemorrhage, coagulation competence, and outcome: A systematic review and stratified meta-analysis.

ABSTRACT:

Background

A meta-analysis concerning perioperative coagulation competence, hemorrhage, and outcome was conducted including the use of hydroxyethyl starches (HESs), dextran, or albumin versus administration of a crystalloid as control to assess the efficacy and safety of colloids and crystalloids for fluid administration during major elective surgery. Surgery was restricted to cardiovascular and noncardiovascular surgery, and HESs were stratified to HES 130/0.4 and HES 200/0.5.

Methods

We searched Cochrane Central Register of Controlled Trials, MEDLINE, ISI Web of Science, EMBASE, conference proceedings, reference lists, and databases of ongoing trials.

Results

Thirty one primary clinical randomized controlled trials included 2287 patients undergoing major surgery fro

SUBMITTER: Rasmussen KC 

PROVIDER: S-EPMC4979852 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature