Autonomous Optimization of Targeted Stimulation of Neuronal Networks.

ABSTRACT: Driven by clinical needs and progress in neurotechnology, targeted interaction with neuronal networks is of increasing importance. Yet, the dynamics of interaction between intrinsic ongoing activity in neuronal networks and their response to stimulation is unknown. Nonetheless, electrical stimulation of the brain is increasingly explored as a therapeutic strategy and as a means to artificially inject information into neural circuits. Strategies using regular or event-triggered fixed stimuli discount the influence of ongoing neuronal activity on the stimulation outcome and are therefore not optimal to induce specific responses reliably. Yet, without suitable mechanistic models, it is hardly possible to optimize such interactions, in particular when desired response features are network-depe

SUBMITTER: Kumar SS 

PROVIDER: S-EPMC4979901 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature