DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner.

ABSTRACT:

Background

Transcription of the HIV-1 provirus is regulated by both viral and host proteins and is very important in the context of viral latency. In latently infected cells, viral gene expression is inhibited as a result of the sequestration of host transcription factors and epigenetic modifications.

Results

In our present study we analyzed the effect of host factor dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) on HIV-1 replication. We show that DYRK1A controls HIV-1 replication by regulating provirus transcription. Downregulation or inhibition of DYRK1A increased LTR-driven transcription and viral replication in cell lines and primary PBMC. Furthermore, inhibition of DYRK1A resulted in reactivation of latent HIV-1 provirus to a similar extent as tw

SUBMITTER: Booiman T 

PROVIDER: S-EPMC4979971 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature