Neural Circuitry of Impaired Emotion Regulation in Substance Use Disorders.

ABSTRACT: Impaired emotion regulation contributes to the development and severity of substance use disorders (substance disorders). This review summarizes the literature on alterations in emotion regulation neural circuitry in substance disorders, particularly in relation to disorders of negative affect (without substance disorder), and it presents promising areas of future research. Emotion regulation paradigms during functional magnetic resonance imaging are conceptualized into four dimensions: affect intensity and reactivity, affective modulation, cognitive modulation, and behavioral control. The neural circuitry associated with impaired emotion regulation is compared in individuals with and without substance disorders, with a focus on amygdala, insula, and prefrontal cortex activation and their

SUBMITTER: Wilcox CE 

PROVIDER: S-EPMC4979988 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature