Genomic Classification and Prognosis in Acute Myeloid Leukemia.

ABSTRACT:

Background

Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice.

Methods

We enrolled a total of 1540 patients in three prospective trials of intensive therapy. Combining driver mutations in 111 cancer genes with cytogenetic and clinical data, we defined AML genomic subgroups and their relevance to clinical outcomes.

Results

We identified 5234 driver mutations across 76 genes or genomic regions, with 2 or more drivers identified in 86% of the patients. Patterns of co-mutation compartmentalized the cohort into 11 classes, each with distinct diagnostic features and clinical outcomes. In additi

SUBMITTER: Papaemmanuil E 

PROVIDER: S-EPMC4979995 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature