Synergistic Interactions of Eugenol-tosylate and Its Congeners with Fluconazole against Candida albicans.

ABSTRACT: We previously reported the antifungal properties of a monoterpene phenol "Eugenol" against different Candida strains and have observed that the addition of methyl group to eugenol drastically increased its antimicrobial potency. Based on the results and the importance of medicinal synthetic chemistry, we synthesized eugenol-tosylate and its congeners (E1-E6) and tested their antifungal activity against different clinical fluconazole (FLC)- susceptible and FLC- resistant C. albicans isolates alone and in combination with FLC by determining fractional inhibitory concentration indices (FICIs) and isobolograms calculated from microdilution assays. Minimum inhibitory concentration (MIC) results confirmed that all the tested C. albicans strains were variably susceptible to the semi-synthetic der

SUBMITTER: Ahmad A 

PROVIDER: S-EPMC4980062 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature