Cobalt-Catalyzed, Aminoquinoline-Directed Functionalization of Phosphinic Amide sp² C-H Bonds.

ABSTRACT: In this paper, we introduce arylphosphinic acid aminoquinoline amides as competent substrates for cobalt-catalyzed sp² C-H bond functionalization. Specifically, the feasibility of their coupling with alkynes, alkenes, and allyl pivalate has been demonstrated. Reactions are catalyzed by simple Co(NO₃)₂ hydrate in ethanol or mixed dioxane/tBuOH solvent in the presence of Mn(OAc)₃·2H₂O additive, sodium pivalate, or acetate base and use oxygen from the air as an oxidant. Directing group removal affords ortho-functionalized P,P-diarylphosphinic acids.

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC4980089 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature