Spiral waves and reentry dynamics in an in vitro model of the healed infarct border zone.

ABSTRACT:

Rationale

Reentry underlies most ventricular tachycardias (VTs) seen postmyocardial infarction (MI). Mapping studies reveal that the majority of VTs late post-MI arise from the infarct border zone (IBZ).

Objective

To investigate reentry dynamics and the role of individual ion channels on reentry in in vitro models of the "healed" IBZ.

Methods and results

We designed in vitro models of the healed IBZ by coculturing skeletal myotubes with neonatal rat ventricular myocytes and performed optical mapping at high temporal and spatial resolution. In culture, neonatal rat ventricular myocytes mature to form striated myocytes and electrically uncoupled skeletal myotubes simulate fibrosis seen in the healed IBZ. High resolution mapping revealed that skeletal myotubes produced l

SUBMITTER: Chang MG 

PROVIDER: S-EPMC4980100 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature