Effect of rosuvastatin on plasma coenzyme Q10 in HIV-infected individuals on antiretroviral therapy.

ABSTRACT:

Background

Coenzyme Q10 (CoQ10) deficiency has been associated with statin-induced myopathy, and supplementation with CoQ10 may reduce inflammation markers. The effects of statins on CoQ10 and its anti-inflammatory properties have not been investigated in HIV-positive patients.

Objective

The objectives of this study were to examine the effect of rosuvastatin on CoQ10 and CoQ10/LDL ratio over 24-week SATURN-HIV trial, explore the associations between CoQ10 levels and markers of vascular disease, inflammation, and immune activation, and assess whether changes in CoQ10 affected the anti-inflammatory effects of statin therapy or were associated with myalgia symptoms.

Methods

This was a secondary analysis of the SATURN-HIV trial, a 96-week randomized clinical trial of 10 m

SUBMITTER: Morrison JT 

PROVIDER: S-EPMC4980145 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature