Effect of iron supplementation on iron stores and total body iron after whole blood donation.

ABSTRACT:

Background

Understanding the effect of blood donation and iron supplementation on iron balance will inform strategies to manage donor iron status.

Study design and methods

A total of 215 donors were randomized to receive ferrous gluconate daily (37.5 mg iron) or no iron for 24 weeks after blood donation. Iron stores were assessed using ferritin and soluble transferrin receptor. Hemoglobin (Hb) iron was calculated from total body Hb. Total body iron (TBI) was estimated by summing iron stores and Hb iron.

Results

At 24 weeks, TBI in donors taking iron increased by 281.0 mg (95% confidence interval [CI], 223.4-338.6 mg) compared to before donation, while TBI in donors not on iron decreased by 74.1 mg (95% CI, -112.3 to -35.9; p < 0.0001, iron vs. no iron). TBI increased

SUBMITTER: Cable RG 

PROVIDER: S-EPMC4980154 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature