Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study.

ABSTRACT:

Introduction

We estimated the prevalence of microinfarcts and their association with dementia in a cohort of oldest-old participants.

Methods

Participants were from The 90+ Study, a population-based study of people 90 years and older. Dementia diagnoses were assigned postmortem during a consensus conference. Microinfarcts were evaluated in six brain regions.

Results

At death, the 213 participants were on average 97 years old, 69% were women, and 52% had dementia. Of the participants, 51% had microinfarcts and 17% had 3+ microinfarcts. The odds ratio (OR) for dementia was similar for 3+ microinfarcts (OR = 4.75, P < .01) and tangle stage V-VI (OR = 4.70, P < .001). Only microinfarcts in cortical regions (other than occipital) were associated to dementia.

Discussion<

SUBMITTER: Corrada MM 

PROVIDER: S-EPMC4980175 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature