Body size measures, hemostatic and inflammatory markers and risk of venous thrombosis: The Longitudinal Investigation of Thromboembolism Etiology.

ABSTRACT:

Objective

Obesity is an important venous thrombosis (VT) risk factor but the reasons for this are unclear.

Materials and methods

In a cohort of 20,914 individuals aged 45 and older without prior VT, we calculated the relative risk (RR) of VT over 12.6years follow-up according to baseline body size measures, and studied whether associations were mediated by biomarkers of hemostasis and inflammation that are related to adiposity.

Results

Greater levels of all body size measures (weight, height, waist, hip circumference, calf circumference, body-mass index, waist-hip ratio, fat mass and fat-free mass) were associated with increased risk of VT, with 4th versus 1st quartile RRs of 1.5-3.0. There were no multiplicative interactions of biomarkers with obesity status. Adjustm

SUBMITTER: Cushman M 

PROVIDER: S-EPMC4980192 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature