Potential impact on blood availability and donor iron status of changes to donor hemoglobin cutoff and interdonation intervals.

ABSTRACT:

Background

A minimum male hemoglobin (Hb) level of 13.0 g/dL becomes a Food and Drug Administration requirement effective May 2016. In addition, extending whole blood (WB) interdonation intervals (IDIs) beyond 8 weeks has been considered to reduce iron depletion in repeat blood donors. This study estimates the impact these changes might have on blood availability and donor iron status.

Study design and methods

Six blood centers participating in Retrovirus Epidemiology Donor Study-II (REDS-II) collected information on all donation visits from 2006 to 2009. Simulations were developed from these data using a multistage approach that first sought to adequately reproduce the patterns of donor return, Hb and ferritin levels, and outcomes of a donor's visit (successful single- or d

SUBMITTER: Spencer BR 

PROVIDER: S-EPMC4980222 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature