Life-course blood pressure in relation to brain volumes.

ABSTRACT:

Introduction

The impact of blood pressure on brain volumes may be time-dependent or pattern-dependent.

Methods

Of 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (∼24 or ∼15 years prior and concurrent with neuroimaging) with late life brain volumes.

Results

Higher diastolic blood pressure ∼24 years prior, higher systolic and pulse pressure ∼15 years prior, and consistently elevated or rising systolic blood pressure from ∼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension ∼15 years prior and hypotension concur

SUBMITTER: Power MC 

PROVIDER: S-EPMC4980244 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature