Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.

ABSTRACT: Variation in the expression level and activity of genes involved in drug disposition and action ('pharmacogenes') can affect drug response and toxicity, especially when in tissues of pharmacological importance. Previous studies have relied primarily on microarrays to understand gene expression differences, or have focused on a single tissue or small number of samples. The goal of this study was to use RNA-sequencing (RNA-seq) to determine the expression levels and alternative splicing of 389 Pharmacogenomics Research Network pharmacogenes across four tissues (liver, kidney, heart and adipose) and lymphoblastoid cell lines, which are used widely in pharmacogenomics studies. Analysis of RNA-seq data from 139 different individuals across the 5 tissues (20-45 individuals per tissue type) revea

SUBMITTER: Chhibber A 

PROVIDER: S-EPMC4980276 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature