Hair analysis for detection of triptans occasionally used or overused by migraine patients-a pilot study.

ABSTRACT:

Purpose

The aim of this study is to evaluate the detection rate of almotriptan, eletriptan, frovatriptan, sumatriptan, rizatriptan, and zolmitriptan in the hair of migraineurs taking these drugs; the degree of agreement between type of self-reported triptan and triptan found in hair; if the concentrations in hair were related to the reported cumulative doses of triptans; and whether hair analysis was able to distinguish occasional use from the overuse of these drugs.

Methods

Out of 300 headache patients consecutively enrolled, we included 147 migraine patients who reported to have taken at least one dose of one triptan in the previous 3 months; 51 % of the patients overused triptans. A detailed pharmacological history and a sample of hair were collected for each patient. Hai

SUBMITTER: Ferrari A 

PROVIDER: S-EPMC4980420 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature