Organizational topology of brain and its relationship to ADHD in adolescents with d-transposition of the great arteries.

ABSTRACT:

Objective

Little is currently known about the impact of congenital heart disease (CHD) on the organization of large-scale brain networks in relation to neurobehavioral outcome. We investigated whether CHD might impact ADHD symptoms via changes in brain structural network topology in a cohort of adolescents with d-transposition of the great arteries (d-TGA) repaired with the arterial switch operation in early infancy and referent subjects. We also explored whether these effects might be modified by apolipoprotein E (APOE) genotype, as the APOE ε2 allele has been associated with worse neurodevelopmental outcomes after repair of d-TGA in infancy.

Methods

We applied graph analysis techniques to diffusion tensor imaging (DTI) data obtained from 47 d-TGA adolescents and 29 healthy

SUBMITTER: Schmithorst VJ 

PROVIDER: S-EPMC4980474 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature