B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS.

ABSTRACT:

Background

Conservative fluid management increases ventilator-free days without influencing overall mortality in acute respiratory distress syndrome. Plasma concentrations of B-type natriuretic peptide (a marker of ventricular filling) or aldosterone (a marker of effective circulating volume) may identify patients for whom fluid management impacts survival.

Methods

This was a retrospective analysis of the Fluid and Catheter Treatment Trial (FACTT), a randomized trial comparing conservative with liberal fluid management in acute respiratory distress syndrome. Using plasma collected at study enrollment, we measured B-type natriuretic peptide and aldosterone by immunoassay. Multivariable analyses examined the interaction between B-type natriuretic peptide or aldosterone concent

SUBMITTER: Semler MW 

PROVIDER: S-EPMC4980545 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature