An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.

ABSTRACT:

Background

Epigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence of cardio-metabolic disease such as: (1) women consistently exhibiting lower mortality than men despite having higher levels of morbidity; (2) racial/ethnic groups having different mortality rates even after adjusting for socioeconomic differences; (3) the black/white mortality cross-over effect in late adulthood; and (4) Hispanics in the United States having a longer life expectancy than Caucasians despite having a higher burden of traditional cardio-metabolic risk factors.

Results

We analyzed blood, saliva, and brain samples from seven different racial/ethnic groups. We assessed the intrinsic epigenetic age acceleratio

SUBMITTER: Horvath S 

PROVIDER: S-EPMC4980791 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature