Enantioselective Synthesis of Spirooxindole Enols: Regioselective and Asymmetric [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Dibenzylidene Ketones.

ABSTRACT: A novel cinchona-alkaloid-derived organocatalyst has been developed to catalyze the asymmetric regioselective [3+2] cycloaddition of 3-isothiocyanato oxindoles with dibenzylidene ketones. A series of spirooxindole enols could be obtained in high yields with good-to-excellent diastereo- and enantioselectivities.

SUBMITTER: Du D 

PROVIDER: S-EPMC4981050 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature