Prevalent Accumulation of Non-Optimal Codons through Somatic Mutations in Human Cancers.

ABSTRACT: Cancer is characterized by uncontrolled cell growth, and the cause of different cancers is generally attributed to checkpoint dysregulation of cell proliferation and apoptosis. Recent studies have shown that non-optimal codons were preferentially adopted by genes to generate cell cycle-dependent oscillations in protein levels. This raises the intriguing question of how dynamic changes of codon usage modulate the cancer genome to cope with a non-controlled proliferative cell cycle. In this study, we comprehensively analyzed the somatic mutations of codons in human cancers, and found that non-optimal codons tended to be accumulated through both synonymous and non-synonymous mutations compared with other types of genomic substitution. We further demonstrated that non-optimal codons were preva

SUBMITTER: Wu X 

PROVIDER: S-EPMC4981346 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature