Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History.

ABSTRACT: The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an inter

SUBMITTER: Gonzalez-Pinto A 

PROVIDER: S-EPMC4981356 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature