A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid.

ABSTRACT: Cataract is the most common cause of visual loss in humans. A spontaneously occurred, autosomal dominant mouse mutant Secc, which displayed combined features of small eye, cataract and closed eyelid was discovered in our laboratory. In this study, we identified the mutation and characterized the cataract phenotype of this novel Secc mutant. The Secc mutant mice have eyelids that remain half-closed throughout their life. The mutant lens has a significant reduction in size and with opaque spots clustered in the centre. Histological analysis showed that in the core region of the mutant lens, the fiber cells were disorganized and clefts and vacuoles were observed. The cataract phenotype was evident from new born stage. We identified the Secc mutation by linkage analysis using whole genome micr

SUBMITTER: Cheng MH 

PROVIDER: S-EPMC4981419 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature