Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases.

ABSTRACT: Flavin-dependent monooxygenases play a variety of key physiological roles and are also very powerful biotechnological tools. These enzymes have been classified into eight different classes (A-H) based on their sequences and biochemical features. By combining structural and sequence analysis, and phylogenetic inference, we have explored the evolutionary history of classes A, B, E, F, and G and demonstrate that their multidomain architectures reflect their phylogenetic relationships, suggesting that the main evolutionary steps in their divergence are likely to have arisen from the recruitment of different domains. Additionally, the functional divergence within in each class appears to have been the result of other mechanisms such as a complex set of single-point mutations. Our results reinfo

SUBMITTER: Mascotti ML 

PROVIDER: S-EPMC4981433 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature