The insulator protein Suppressor of Hairy wing is required for proper ring canal development during oogenesis in Drosophila.

ABSTRACT: Chromatin insulators orchestrate gene transcription during embryo development and cell differentiation by stabilizing interactions between distant genomic sites. Mutations in genes encoding insulator proteins are generally lethal, making in vivo functional analyses of insulator proteins difficult. In Drosophila, however, mutations in the gene encoding the Suppressor of Hairy wing insulator protein [Su(Hw)] are viable and female sterile, providing an opportunity to study insulator function during oocyte development. Whereas previous reports suggest that the function of Su(Hw) in oogenesis is independent of its insulator activity, many aspects of the role of Su(Hw) in Drosophila oogenesis remain unexplored. Here we show that mutations in su(Hw) result in smaller ring canal lumens and smaller

SUBMITTER: Hsu SJ 

PROVIDER: S-EPMC4981481 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature