Ontology highlight
ABSTRACT:
SUBMITTER: Padanad MS
PROVIDER: S-EPMC4981512 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cell reports 20160728 6
KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coenzyme A (CoA) synthetase long-chain family member 3 (ACSL3), which converts fatty acids into fatty Acyl-CoA esters, the substrates for lipid synthesis and β-oxidation. ACSL3 suppress ...[more]