FARVATX: Family-Based Rare Variant Association Test for X-Linked Genes.

ABSTRACT: Although the X chromosome has many genes that are functionally related to human diseases, the complicated biological properties of the X chromosome have prevented efficient genetic association analyses, and only a few significantly associated X-linked variants have been reported for complex traits. For instance, dosage compensation of X-linked genes is often achieved via the inactivation of one allele in each X-linked variant in females; however, some X-linked variants can escape this X chromosome inactivation. Efficient genetic analyses cannot be conducted without prior knowledge about the gene expression process of X-linked variants, and misspecified information can lead to power loss. In this report, we propose new statistical methods for rare X-linked variant genetic association analys

SUBMITTER: Choi S 

PROVIDER: S-EPMC4981534 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature