Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study.

ABSTRACT:

Purpose

Although targeted sequencing improves outcomes for many cancer patients, it remains uncertain how somatic and germ-line whole-exome sequencing (WES) will integrate into care.

Methods

We conducted surveys and interviews within a study of WES integration at an academic center to determine oncologists' attitudes about WES and to identify lung and colorectal cancer patients' preferences for learning WES findings.

Results

One-hundred sixty-seven patients (85% white, 58% female, mean age 60) and 27 oncologists (22% female) participated. Although oncologists had extensive experience ordering somatic tests (median 100/year), they had little experience ordering germ-line tests. Oncologists intended to disclose most WES results to patients but anticipated numerous chall

SUBMITTER: Gray SW 

PROVIDER: S-EPMC4981555 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature