Functional resting-state connectivity of the human motor network: differences between right- and left-handers.

ABSTRACT: Handedness is associated with differences in activation levels in various motor tasks performed with the dominant or non-dominant hand. Here we tested whether handedness is reflected in the functional architecture of the motor system even in the absence of an overt motor task. Using resting-state functional magnetic resonance imaging we investigated 18 right- and 18 left-handers. Whole-brain functional connectivity maps of the primary motor cortex (M1), supplementary motor area (SMA), dorsolateral premotor cortex (PMd), pre-SMA, inferior frontal junction and motor putamen were compared between right- and left-handers. We further used a multivariate linear support vector machine (SVM) classifier to reveal the specificity of brain regions for classifying handedness based on individual restin

SUBMITTER: Pool EM 

PROVIDER: S-EPMC4981638 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature