The effect of aliskiren on the renal dysfunction following unilateral ureteral obstruction in the rat.

ABSTRACT:

Purpose

To investigate the effect of blocking renin-angiotensin system by direct renin inhibition using aliskiren on the renal dysfunction following reversible unilateral ureteral obstruction (UO).

Methods

Wistar rats underwent reversible left UO for 72 hours. Group-Alsk (n=12) received aliskiren (30 mg/kg/day) dissolved in water starting one day before creating UO and continued until the terminal experiment five days post reversal when renal functions were measured using clearance techniques. Group-Vx (n=12) underwent similar protocol but had water only. Gene expression analysis of some markers of kidney injury was measured using PCR technique.

Results

In Group-Vx, renal blood flow (RBF) and glomerular filtration rate (GFR) in the left kidney were significantly lower

SUBMITTER: Hammad FT 

PROVIDER: S-EPMC4981651 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature