DamX Controls Reversible Cell Morphology Switching in Uropathogenic Escherichia coli.

ABSTRACT:

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The ability to change cell morphology is an advantageous characteristic adopted by multiple pathogenic bacteria in order to evade host immune detection and assault during infection. Uropathogenic Escherichia coli (UPEC) exhibits such cellular dynamics and has been shown to transition through a series of distinct morphological phenotypes during a urinary tract infection. Here, we report the first systematic spatio-temporal gene expression analysis of the UPEC transition through these phenotypes by using a flow chamber-based in vitro infection model that simulates conditions in the bladder. This analysis revealed a novel association between the cell division gene damX and reversible UPEC filamentation. We demonstrate a lack of reversible bacterial filamentation in a damX d

SUBMITTER: Khandige S 

PROVIDER: S-EPMC4981707 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature