Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds.

ABSTRACT: Gliomas are the most common primary brain tumors either benign or malignant originating from the glial tissue. Glioblastoma multiforme (GBM) is the most prevalent and aggressive form among all gliomas, associated with decimal prognosis due to it`s high invasive nature. GBM is also characterized by high recurrence rate and apoptosis resistance features which make the therapeutic targeting very challenging. Mitochondria are key cellular organelles that are acting as focal points in diverse array of cellular functions such as cellular energy metabolism, regulation of ion homeostasis, redox signaling and cell death. Eventual findings of mitochondrial dysfunction include preference of glycolysis over oxidative phosphorylation, enhanced reactive oxygen species generation and abnormal mitochondri

SUBMITTER: Guntuku L 

PROVIDER: S-EPMC4981742 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature