Transcriptome analysis reveals regional and temporal differences in mucosal immune system development in the small intestine of neonatal calves.

ABSTRACT:

Background

Postnatal development of the mammalian mucosal immune system is crucial for responding to the rapid colonization by commensal bacteria and possible exposure to pathogens. This study analyzed expression patterns for mRNAs and their relationship with microRNAs (miRNAs) in the bovine small intestine during the critical neonatal period (0 to 42 days). This analysis revealed molecular mechanisms regulating the postnatal development of the intestinal mucosal immune system.

Results

Small intestine samples (jejunum and ileum) were collected from newborn male, Holstein calves immediately post-partum (n = 3) and at 7 (n = 5), 21 (n = 5), and 42 (n = 5) days of age and the transcriptomes were profiled using RNA-Seq. When analyzing all time points collectively, greater expres

SUBMITTER: Liang G 

PROVIDER: S-EPMC4981982 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature