Vaccinating with conserved Escherichia coli antigens does not alter the mouse intestinal microbiome.

ABSTRACT:

Background

Enterotoxigenic Escherichia coli (ETEC) causes diarrheal disease. Antigenic and structural heterogeneity among ETEC colonization factors has complicated vaccine development efforts. Identifying and characterizing conserved ETEC antigens that induce protective immunity is therefore of interest. We previously characterized three proteins (MipA, Skp, and ETEC_2479) that protected mice in an intranasal ETEC challenge model after vaccination. However, these proteins are conserved not only in multiple ETEC isolates, but also in commensal bacteria. While the impact of inactivated viral vaccines and live-attenuated bacterial vaccines on the host microbiota have been examined, the potential impact of using subunit vaccines consisting of antigens that are also encoded by commensal

SUBMITTER: Hays MP 

PROVIDER: S-EPMC4981990 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature