L-arginine promotes gut hormone release and reduces food intake in rodents.

ABSTRACT:

Aims

To investigate the anorectic effect of L-arginine (L-Arg) in rodents.

Methods

We investigated the effects of L-Arg on food intake, and the role of the anorectic gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), the G-protein-coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents.

Results

Oral gavage of L-Arg reduced food intake in rodents, and chronically reduced cumulative food intake in diet-induced obese mice. Lack of the GPRC6A in mice and subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. L-Arg stimulated GLP-1 and PYY release in vitro and in vivo. Pharmacological blockade of GLP-1 and PYY receptors did not influence the anorectic effect of L-Arg. L

SUBMITTER: Alamshah A 

PROVIDER: S-EPMC4982043 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature