TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms within the TAS2R38 gene have been implicated as possible contributors to the complex gene-environment interactions in CRS. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype, CRS and related comorbidities.

Methods

Fifty-three CRS patients and 39 healthy individuals were genotyped at the TAS2R38 locus. CRS patients were treated by endoscopic sinus surgery and medical therapies and subdivided in CRS with nasal polyps (CRSwNPs) and CRS without nasal polyps (CRSsNPs). The effect of genotype on CRS and CRS-related comorbidities was assessed.

Results

The distribution of the di

SUBMITTER: Gallo S 

PROVIDER: S-EPMC4982233 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature