Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life.

ABSTRACT: The autonomic nervous system plays a critical role in glucose metabolism through both its sympathetic and parasympathetic branches, but the mechanisms that underlie the development of the autonomic innervation of the pancreas remain poorly understood. Here, we report that cholinergic innervation of pancreatic islets develops during mid-gestation under the influence of leptin. Leptin-deficient mice display a greater cholinergic innervation of pancreatic islets beginning in embryonic life, and this increase persists into adulthood. Remarkably, a single intracerebroventricular injection of leptin in embryos caused a permanent reduction in parasympathetic innervation of pancreatic β cells and long-term impairments in glucose homeostasis. These developmental effects of leptin involve a direct i

SUBMITTER: Croizier S 

PROVIDER: S-EPMC4982372 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature