Ontology highlight
ABSTRACT:
SUBMITTER: Schott JM
PROVIDER: S-EPMC4982482 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160315 8
<h4>Introduction</h4>The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.<h4>Methods</h4>We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study.<h4>Results</h4>We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2. ...[more]