Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium.

ABSTRACT:

Aims

Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to evaluate the improved eligibility for statin therapy based on elevated troponin I concentrations retrospectively.

Methods and results

Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective population-based studies including 74 738 participants. We investigated the value of adding troponin I levels to conventional risk factors for prediction of cardiovascular disease by calcu

SUBMITTER: Blankenberg S 

PROVIDER: S-EPMC4982535 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature