Ontology highlight
ABSTRACT:
SUBMITTER: Sweeney NP
PROVIDER: S-EPMC4982542 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sweeney Nathan Paul NP Regan Cathy C Liu Jiahui J Galleu Antonio A Dazzi Francesco F Lindemann Dirk D Rupar Charles Anthony CA McClure Myra Olga MO
Molecular therapy : the journal of the American Society of Gene Therapy 20160502 7
Mesenchymal stromal cells (MSCs) hold great promise for regenerative medicine. Stable ex vivo gene transfer to MSCs could improve the outcome and scope of MSC therapy, but current vectors require multiple rounds of transduction, involve genotoxic viral promoters and/or the addition of cytotoxic cationic polymers in order to achieve efficient transduction. We describe a self-inactivating foamy virus vector (FVV), incorporating the simian macaque foamy virus envelope and using physiological promot ...[more]