Design, synthesis and evaluation of novel ¹⁹F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

ABSTRACT: Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent and ¹⁹F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4982551 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature