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Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

ABSTRACT: Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent and 19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4982551 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Design, synthesis and evaluation of novel <sup>19</sup>F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

Li Yu Y   Xia Guiquan G   Guo Qi Q   Wu Li L   Chen Shizhen S   Yang Zhigang Z   Wang Wei W   Zhang Zhong-Yin ZY   Zhou Xin X   Jiang Zhong-Xing ZX  

MedChemComm 20160620 8

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent and <sup>19</sup>F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy. ...[more]

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