High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy.

ABSTRACT: Myeloid-derived suppressor cells are immune-suppressive cells that are elevated in most individuals with cancer, where their accumulation and suppressive activity are driven by inflammation. As myeloid-derived suppressor cells inhibit anti-tumor immunity and promote tumor progression, we are determining how their viability is regulated. Previous studies have established that the damage-associated molecular pattern molecule high-mobility group box protein 1 drives myeloid-derived suppressor cell accumulation and suppressive potency and is ubiquitously present in the tumor microenvironment. As high-mobility group box protein 1 also facilitates tumor cell survival by inducing autophagy, we sought to determine if high-mobility group box protein 1 regulates myeloid-derived suppressor cell survi

SUBMITTER: Parker KH 

PROVIDER: S-EPMC4982609 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature