The Shift of ERG B-Wave Induced by Hours' Dark Exposure in Rodents.

ABSTRACT:

Purpose

Dark adaptation can induce a rapid functional shift in the retina, and after that, the retinal function is believed to remain stable during the continuous dark exposure. However, we found that electroretinograms (ERG) b-waves gradually shifted during 24 hours' dark exposure in rodents. Detailed experiments were designed to explore this non-classical dark adaptation.

Methods

In vivo ERG recording in adult and developing rodents after light manipulations.

Results

We revealed a five-fold decrease in ERG b-waves in adult rats that were dark exposed for 24 hours. The ERG b-waves significantly increased within the first hour's dark exposure, but after that decreased continuously and finally attained steady state after 1 day's dark exposure. After 3 repetitive, 10 mi

SUBMITTER: Li D 

PROVIDER: S-EPMC4982619 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature