Visualization and analysis of biomaterial-centered thrombus formation within a defined crevice under flow.

ABSTRACT: The blood flow pathway within a device, together with the biomaterial surfaces and status of the patient's blood, are well-recognized factors in the development of thrombotic deposition and subsequent embolization. Blood flow patterns are of particular concern for devices such as blood pumps (i.e. ventricular assist devices, VADs) where shearing forces can be high, volumes are relatively large, and the flow fields can be complex. However, few studies have examined the effect of geometric irregularities on thrombus formation on clinically relevant opaque materials under flow. The objective of this study was to quantify human platelet deposition onto Ti6Al4V alloys, as well as positive and negative control surfaces, in the region of defined crevices (∼50-150 μm in width) that might be encoun

SUBMITTER: Jamiolkowski MA 

PROVIDER: S-EPMC4982661 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature