Changes, and the Relevance Thereof, in Mitochondrial Morphology during Differentiation into Endothelial Cells.

ABSTRACT: The roles of mitochondria in various physiological functions of vascular endothelial cells have been investigated extensively. Morphological studies in relation to physiological functions have been performed. However, there have been few reports of morphological investigations related to stem cell differentiation. This was the first morphological study of mitochondria in relation to endothelial differentiation and focused on quantitative analysis of changes in mitochondrial morphology, number, area, and length during differentiation of human mesenchymal stem cells (hMSCs) into endothelial-like cells. To induce differentiation, we engaged vascular endothelial growth factors and flow-induced shear stress. Cells were classified according to the expression of von Willebrand factor as hMSCs, di

SUBMITTER: Shin JW 

PROVIDER: S-EPMC4982679 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature